ⓘ Chloride anion exchanger

                                     

ⓘ Chloride anion exchanger

Protein DRA is a membrane protein in intestinal cells. It is an anion exchanger and a member of the sulfate anion transporter SAT family. It mediates chloride and bicarbonate exchange and additionally transports sulfate and other anions at the apical membrane, part of the plasma membrane of enterocytes. It is different from the anion exchanger that present in erythrocytes, renal tubule, and several other tissues.

The protein encoded by this gene, is a transmembrane glycoprotein that functions as a sulfate Transporter. Is localized on the mucosa of the lower intestine, especially in the apical membrane of the columnar epithelium and some goblet cells, and plays an important role in chloride uptake, helping in creating the osmotic gradient for the reabsorption of fluid from the lumen of the intestine.