Tyrosyl-tRNA synthetase, cytoplasmic, also known as Tyrosine-tRNA ligase, is an enzyme that in humans is encoded by the YARS gene.

Living cells to translate DNA sequences into RNA sequences and then the sequence of the protein. Proteins are chains of amino acids such as tyrosine. As the protein grows, each amino acid is added at the end by the enzyme called RNA transport tRNA. Each amino acid has its own tRNA and tyrosyl-tRNA synthetase tRNA-it is something that adds tyrosine to the end of the growing protein.

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by transferring their cognate amino acids. Because of their Central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are considered to be one of the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. The activity of the cytokine was observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, the N-terminal fragment that harbors the catalytic site and the C-terminal fragment is found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is a company emap and the other as a cytokine.

Recently, tyrosyl-tRNA synthetase proven to be biologically and functionally significant targets for resveratrol.

For comparison, human cytoplasmic tyrosyl-tRNA synthetase of mitochondria with his colleague and synthetases tyrosyl-tRNA other biological kingdoms of organisms can be found in Wikipedia on tyrosine-tRNA ligase and an overview of their structure and function.