ⓘ PDCD4

                                     

ⓘ PDCD4

This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.

                                     
  • Programmed cell death protein 10 is a protein that in humans is encoded by the PDCD 10 gene. This gene encodes a protein, originally identified in a premyeloid
  • gene dispersed through the genome. RPS13 has been shown to interact with PDCD4 GRCh38: Ensembl release 89: ENSG00000110700 - Ensembl, May 2017 GRCm38:
  • known as PD - L2, B7 - DC is a protein that in humans is encoded by the PDCD 1LG2 gene. PDCD 1LG2 has also been designated as CD273 cluster of differentiation
  • Programmed cell death protein 7 is a protein that in humans is encoded by the PDCD 7 gene. This gene encodes a protein with sequence similarity to a mouse protein
  • death 6 - interacting protein is a protein that in humans is encoded by the PDCD 6IP gene. This gene encodes a protein thought to participate in programmed
  • Programmed cell death protein 6 is a protein that in humans is encoded by the PDCD 6 gene. This gene encodes a calcium - binding protein belonging to the penta - EF - hand
  • of eIF 4 A1. Conversely, eIF 4 A1 activity is suppressed when it is bound to PDCD4 a tumor suppressor itself modulated by mTOR and miR - 21. PCDC 4 is typically
  • Up - regulation of PDCD4 in senescent human diploid fibroblasts Biochem. Biophys. Res. Commun. 293 1 617 21. doi: 10.1016 S0006 - 291X 02 00264 - 4 PMID 12054647
  • treat certain types of cancer. The PD - 1 protein in humans is encoded by the PDCD 1 gene. PD - 1 is a cell surface receptor that belongs to the immunoglobulin
  • Protein 4 PDCD4 is known to inhibit ATG5 expression via inhibition of protein translation. Two MA3 domains on PDCD4 bind to RNA - helicase EIF 4 A, preventing