ⓘ NRXN1

                                     

ⓘ NRXN1

Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene.

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three genes NRXN1-3 use of two alternate promoters and include numerous alternative spliced exons to generate thousands of different isoforms of mRNA transcripts and protein. Most transcripts are formed from the upstream promoter and encode alpha-neurexin isoforms, a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor EGF-like sequences and laminin g domains and has been shown to interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin g Domains than alpha-neurexins.

                                     
  • several unlinked genes of which two, NRXN1 and NRXN 3, are among the largest known human genes. Three of the genes NRXN1 - 3 utilize two alternate promoters
  • several unlinked genes of which two, NRXN1 and NRXN 3, are among the largest known human genes. Three of the genes NRXN1 - 3 utilize two alternate promoters
  • NRXN1 NRXN 2, and NRXN 3 each controlled by two different promoters, an upstream alpha α and a downstream beta β resulting in alpha - neurexins 1 - 3
  • central nervous system synapses. NLGN 1 has been shown to interact with NRXN1 and DLG4. Neurexins: NRXN1 NRXN 2, NRXN 3 GRCh38: Ensembl release 89: ENSG00000169760
  • Figures 5 and 6 have 99 structural similarity to the protein neurexin 1 - alpha NRXN1 Neurexins are cell adhesion molecules and often contain EGF binding
  • relation between schizophrenia and deletions at 1 q21. 1 3q29, 15q13.3, 22q11.21 en Neurexin 1 NRXN1 and duplications at 16p11.2 are at 7.5 or higher
  • several genes that have been linked to individual linguistic ability. The NRXN1 gene has been linked to general language ability, and mutations of this
  • CNTNAP2 gene on the long arm of chromosome 7 7q33 - q36 and the neurexin 1 alpha NRXN1 gene on the short arm of chromosome 2 2p16.3 Malformations in the
  • relation between schizophrenia and deletions at 1 q21. 1 3q29, 15q13.3, 22q11.21 en Neurexin 1 NRXN1 and duplications at 16p11.2 are at 7.5 or higher
  • Orrico A, Ousager LB, Collins AL, et al. November 2009 CNTNAP2 and NRXN1 are mutated in autosomal - recessive Pitt - Hopkins - like mental retardation