ⓘ Signal transducing adaptor molecule

                                     

ⓘ Signal transducing adaptor molecule

This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains an SH3 domain and the immunoreceptor tyrosine-based activation motif ITAM. This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS hepatocyte growth factor-regulated tyrosine kinase substrate has been found to bind and counteract the function of this protein.

                                     
  • Signal transducing adaptor proteins STAPs are proteins that are accessory to main proteins in a signal transduction pathway. Adaptor proteins contain
  • Signal transducing adapter molecule 2 is a protein that in humans is encoded by the STAM2 gene. The protein encoded by this gene is closely related to
  • refer to: Ghent City Museum in Dutch: Stadsmuseum Gent Signal transducing adaptor molecule a human gene Science and Technology of Advanced Materials
  • Cytokine - mediated signal transduction in the JAK - STAT cascade requires the involvement of adaptor molecules One such signal - transducing adaptor molecule contains
  • insight into modest binding of a non - PXXP ligand to the signal transducing adaptor molecule - 2 Src homology 3 domain J. Biol. Chem. 278 48 48162 8
  • adapter molecules within the cytoplasm of cells in order to propagate a signal Four adaptor molecules are known to be involved in signaling which are
  • to interact with: CLTC DLG4, EPS15, IL2RB, Merlin, STAM2, Signal transducing adaptor molecule TSG101. PDBe - KB provides an overview of all the structure
  • for computer programming Signal transducing adaptor protein, a type of protein involved in cell signalling Blank - firing adaptor a device which enables
  • cell - signaling events. All cells receive and respond to signals from their surroundings. This is accomplished by a variety of signal molecules that are
  • C, Su X, Chen PI, Stahl PD 2007 Rin1 interacts with signal - transducing adaptor molecule STAM and mediates epidermal growth factor receptor trafficking