ⓘ SAG (gene)

                                     

ⓘ SAG (gene)

S-arrestin is a protein that in humans is encoded by the SAG gene.

Members to arrest / beta family protein to arrest, believed to participate in agonist-mediated desensitization of G-protein-paired receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. With-to arrest, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization photoactivation of the transduction cascade. This is expressed in the retina and pineal gland and inhibits the coupling of rhodopsin to transducin in vitro. In addition, is to arrest the high antigenic and capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with disease Oguchi, a rare autosomal recessive form of night blindness.