ⓘ ADD2

                                     

ⓘ ADD2

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta, and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues.

And adducins alpha and gamma radiation ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, it was found that heterodimer of alpha and beta adducins. Polymorphisms result in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimer consisting of alpha and gamma subunits have also been described. Structurally, each subunit consists of two domains.

The amino-terminal region is protease resistant and round shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site calmodulin, and is required for Association with spectrin and actin. Different beta adducin mRNA, alternative spliced at the 3end and / or internally spliced and encode different isoforms have been described. The functions of the different isoforms is not known.

                                     
  • designated as ADD2 advanced digital display, second generation or the more feature - rich MEC media expansion card MEC is sometimes designated as ADD2 in Intel
  • Lozovatsky L, Gwynn B, et al. 1999 Targeted disruption of the β adducin gene Add2 causes red blood cell spherocytosis in mice Proc. Natl. Acad. Sci. U.S
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  • Assignment of the human beta - adducin gene ADD2 to 2 p13 - p14 by in situ hybridization Genomics. 28 3 610 2 doi: 10.1006 geno.1995.1205. PMID 7490111
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