ⓘ SIAH2

                                     

ⓘ SIAH2

This gene encodes a protein that is a member of the seven in absentia homolog SIAH family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.