ⓘ RFC2

                                     

ⓘ RFC2

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen PCNA and replication factor C RFC. RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described.

                                     
  • the same protein have been reported. RFC 4 has been shown to interact with: BRD4, CHTF18, PCNA, RFC2 RFC 3, and RFC 5. GRCh38: Ensembl release 89: ENSG00000163918
  • the 36.5 - kDa RFC 5 37 - kDa RFC 4 38 - kDa RFC 3 and 40 - kDa RFC2 subunit genes of human replication factor C to chromosome bands 12q24. 2 - q24.3, 3q27
  • distinct isoforms have been reported. RFC 5 has been shown to interact with: BRD4, CHTF18, PCNA, RFC2 and RFC 4. GRCh38: Ensembl release 89: ENSG00000111445
  • or RFC is a five - subunit protein complex that is required for DNA replication. The subunits of this heteropentamer are named Rfc 1, Rfc2 Rfc 3, Rfc 4, and
  • loader of prokaryotes. The eukaryotic equivalent to the DNA clamp loader is Replication Factor C, which is encoded by RFC 1, RFC2 RFC 3, RFC 4, and RFC 5.
  • Vaziri C, Ohmori H, Todo T Apr 2008 DNA damage - induced ubiquitylation of RFC2 subunit of replication factor C complex J. Biol. Chem. 283 14 9071 9
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