ⓘ FGF8

                                     

ⓘ FGF8

The protein encoded by this gene is a member of the fibroblast growth factor FGF family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

Fgf8 is important and necessary to create and maintain brain / hindbrain boundary and the midbrain / meth border of the brain, which plays a critical role" organizer” in the development, as Spemann" organizer of the” embryo gastrulating. Fgf8 is expressed in the region where Otx2 and Gbx2 cross inhibit each other and supported by the expression of this interaction. Once expressed, Fgf8 induces other transcription factors to form a cross-regulatory loops between the cells, thus, boundaries are established. Through the development, Fgf8 is regulate growth and differentiation of progenitor cells in this region to obtain the final structure of the midbrain and hindbrain. Crossely experiment proves that Fgf8 is sufficient to cause the repatterning of the midbrain and hindbrain structures.

In the development of the forebrain, cortical patterning centers of the edges or poles of the cortical rudiment, in which several Wnt and BMP genes is expressed. In addition, at the anterior pole a few FGF family, including Fgf3, 8.17 and 18 intersect in the expression. The similarity in cortical gene expression in Emx2 mutants and mice in which the anterior FGF8 source is augmented suggests that FGF8 controls the phased expressionlow front, high back Emx2 in the cortical primordium. Emx2 is one of the protomap molecular determinants, which are closely interacted with Pax6. Emx2 and Pax6 are expressed in opposing gradients along the axis of a / P cortical primordium and cooperate to configure the template area. Fgf8 and Emx2 antagonizing with each other, to create a map of development. Fgf8 contributes to the development of the front and rear suppresses fate, while Emx2, quite the contrary. Moreover, the manipulation of FGF8 controls offer estimated cortical expression of coup-TF1. In addition, the sharpness of both COUPTF1 and coup-TF2 expression boundaries would be expected from genes involved in the specification of the border.Thus, the engagement between them regulates the axis / P cortical primordium and sends the map development area of the cortex.

                                     
  • but Fgf 4 is also able to rescue all skeletal defects that arise from the lack of Fgf8 Therefore, the Fgf 4 gene compensates for the loss of the Fgf8 gene
  • distal limb structures. Sp 8 and Sp9 mediate Fgf 10 signaling, which in turn regulates Fgf8 expression Fgf 10 - - - Fgf8 Fgf8 is essential for normal limb
  • PMID 10381577. Xu J, Liu Z, Ornitz DM 2000 Temporal and spatial gradients of Fgf8 and Fgf 17 regulate proliferation and differentiation of midline cerebellar structures
  • factor 7 FGF 7 Fibroblast growth factor 8 FGF8 Fibroblast growth factor 9 FGF 9 Fibroblast growth factor 10 FGF 10 Fibroblast growth factor 11 FGF 11 Fibroblast
  • stimulate the production of FGF 10 in the lateral plate mesoderm where it will create an epithelial - mesenchymal FGF signal with FGF8 This positive feedback
  • function together, FGF 4 and FGF8 17 in Xenopus and FGF8 and FGF 24 in zebrafish 18 is necessary for mesoderm formation. Both FGF signaling and Xbra
  • growth factor 8 Fgf8 Out of the known isoforms of Fgf8 Fgf 8 a and Fgf 8 b have been shown to be expressed at the isthmic organizer with Fgf 8 b being prevalent
  • Birnbaum D, Mason I Mar 1995 Mouse Fgf 7 fibroblast growth factor 7 and Fgf8 fibroblast growth factor 8 genes map to chromosomes 2 and 19 respectively
  • PMID 10353607. Xu J, Liu Z, Ornitz DM 2000 Temporal and spatial gradients of Fgf8 and Fgf 17 regulate proliferation and differentiation of midline cerebellar structures
  • which expresses FGF8 The AER is known to express FGF 2, FGF 4, FGF8 and FGF 9, while the limb bud mesenchyme expresses FGF 2 and FGF 10. Embryo manipulation
  • generated just anterior to the caudal FGF8 domain which limits the anterior spreading of FGF8 retinoic acid repression of Fgf8 gene expression defines the wavefront
  • by WNT 8 C or WNT2B. FGF 10 expression activates secretion of WNT3A, which acts upon the AER and induces FGF8 expression. The mesenchyme, through FGF 10 secretion