ⓘ EGLN1

                                     

ⓘ EGLN1

Hypoxia-inducible factor prolyl hydroxylase 2, or prolyl hydroxylase domain-containing protein 2, is an enzyme encoded by the EGLN1 gene. It is also known as Egl nine homolog 1. PHD2 is a α-ketoglutarate/2-oxoglutarate-dependent hydroxylase, a superfamily non-haem iron-containing proteins. In humans, PHD2 is one of the three isoforms of hypoxia-inducible factor-proline dioxygenase, which is also known as HIF prolyl-hydroxylase.

                                     
  • Egl nine homolog 2 is a protein that in humans is encoded by the EGLN 2 gene. ELGN2 is a alpha - ketoglutarate - dependent hydroxylase, a superfamily of non - haem
  • Egl nine homolog 3 is a protein that in humans is encoded by the EGLN 3 gene. ELGN3 is a member of the superfamily of alpha - ketoglutarate - dependent hydroxylases
  • RAB4B - EGLN 2 readthrough NMD candidate is a protein that in humans is encoded by the RAB4B - EGLN 2 gene. This locus represents naturally occurring read - through
  • acid oxidation. EGLN1 codes for an enzyme, prolyl hydroxylase 2 PHD2 involved in erythropoiesis. Among the Tibetans, mutation in EGLN1 specifically
  • α - ketoglutarate helps the reaction by being oxidized with the main substrate. EGLN1 one of the α - ketoglutarate - dependent oxygenases, is an O2 sensor, informing
  • axonemal, heavy chain 14 ECM 1 1 q21 EDEM3: ER degradation enhancing alpha - mannosidase like protein 3 EGLN1 1 q42 ENAH 1 q42 ESRRG 1 q41 FAM20B: FAM20B, glycosaminoglycan
  • Variation Consortium, Basu A, Mukerji M. 2011 Am J Hum Genet. 89 1 111 - 120. EGLN1 involvement in high - altitude adaptation revealed through genetic analysis
  • associations between EPAS 1 or EGLN1 and hemoglobin concentration, indicating variation in the pattern of molecular adaptation. However, EGLN1 appears to be the
  • Genetics and Cytogenetics in Oncology and Haematology. ENG Gene - EGLN Protein EGLN Antibody GeneCards. Fernandez - Ruiz E, St - Jacques S, Bellon T, Letarte
  • 2 - hydroxyglutarate linked to EGLN activation PDF Nature. 483 7390 484 8. doi: 10.1038 nature10898. PMC 3656605. PMID 22343896.CS 1 maint: uses authors parameter
  • interacts with egl nine homolog 3 EGLN 3, also known as PHD3 and regulates expression of hypoxia - inducible factor 1 and has been purified as part of