ⓘ UPF2

                                     

ⓘ UPF2

This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay NMD. When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene, both variants encode the same protein. UPF2 has recently been shown to alter adult behavior via alterations in hippocampal synaptic spine density and the late long-term potentiation of neurons.

                                     
  • this gene. UPF1 has been shown to interact with: DCP1A, DCP 2 SMG1, UPF2 UPF 3A, and UPF 3B. GRCh38: Ensembl release 89: ENSG00000005007 - Ensembl, May
  • different isoforms have been found for this gene. UPF 3B has been shown to interact with UPF2 and UPF 1. GRCh38: Ensembl release 89: ENSG00000125351 - Ensembl
  • different isoforms have been found for this gene. UPF 3A has been shown to interact with RBM8A, UPF2 and UPF 1. GRCm38: Ensembl release 89: ENSMUSG00000038398
  • provide a binding for UPF 3, which acts as a bridge between UPF2 and UPF 1 forming a trimeric complex. Within this complex, UPF2 and UPF 3 act cooperatively
  • cerevisiae yeast there are three main factors in NMD: UPF 1, UPF2 and UPF 3 UPF 3A and UPF 3B in humans that make up the conserved core of the NMD pathway
  • cap is bound by the mRNA decapping enzyme DCP 2 A host of proteins accompany it including UPF 1, UPF2 UPF 3A, Dcp1, Dhh1, XRN1, and others. The decapping
  • cerevisiae Dcp 2 is joined by the decapping activator Dcp1, the helicase Dhh1, the exonuclease Xrn1, nonsense mediated decay factors Upf 1, Upf2 and Upf 3, the
  • conserved in the process of NMD. These are the Upf 1 SMG - 2 Upf2 SMG - 3 and Upf 3 SMG - 4 complexes. Upf 1 SMG - 2 is a phosphoprotein in multicellular organisms
  • C7orf25 protein UPF 0415 UPF 0415 is a protein encoded on chromosome 7, in open reading frame 25 C7orf25 and are located at domain of unknown function
  • uses and continued in production through the late 1930s. The tandem cockpit UPF - 7 was adopted by the Civilian Pilot Training Program and continued in production
  • Unified Power Format UPF is the popular name of the Institute of Electrical and Electronics Engineers IEEE standard for specifying power intent in