ⓘ Serglycin

                                     

ⓘ Serglycin

Serglycin, also known as hematopoetic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the SRGN gene. It is primarily expressed in hematopoietic cells and endothelial cells, and is the only known intracellular proteoglycan.

                                     
  • 29 - 30 amino acids HNPs associate with the negatively charged proteoglycan serglycin and translocate to azurophil granules. At later stages of granulocytic
  • Frantz C, Shostak I, Sawchuk T, Bleackley R 2004 The granzyme B - serglycin complex from cytotoxic granules requires dynamin for endocytosis Blood
  • acidic CTL granules. The enzyme is also rendered inactive when bound by serglycin in the granules to avoid apoptosis triggering inside the cytotoxic T cells
  • PMID 8511754. Kolset SO, Mann DM, Uhlin - Hansen L, et al. 1996 Serglycin - binding proteins in activated macrophages and platelets J. Leukoc. Biol
  • SPG9 encoding protein Spastic paraplegia 9 autosomal dominant SRGN: serglycin STAMBPL1: STAM binding protein like 1 STOX1: encoding protein Storkhead