ⓘ ATP6V1B1

                                     

ⓘ ATP6V1B1

V-type proton ATPase subunit B, kidney isoform is an enzyme that in humans is encoded by the ATP6V1B1 gene.

This gene encodes a component vacuolar ATPase V-ATPase, a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane v0 domain. B1 domain consists of three and three B subunits, two g subunits plus the C, D, E, F, and H subunits. V1 domain contains the ATP catalytic site. The v0 domain consists of five different subunits: a, C C, and d. Additional isoforms of many of the V1 and v0 subunit proteins are encoded by multiple genes or alternative splicing variants of transcripts. This encoded protein is one of two V1 domain b subunit isoforms and is found in the kidneys. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness.

                                     
  • V - type proton ATPase subunit B brain isoform is an enzyme that in humans is encoded by the ATP 6 V 1 B 2 gene. This gene encodes a component of vacuolar ATPase
  • V - type proton ATPase subunit C 1 is an enzyme that in humans is encoded by the ATP 6 V 1 C 1 gene. This gene encodes a component of vacuolar ATPase V - ATPase
  • V - type proton ATPase catalytic subunit A is an enzyme that in humans is encoded by the ATP 6 V 1 A gene. This gene encodes a component of vacuolar ATPase
  • V - type proton ATPase subunit G 1 is an enzyme that in humans is encoded by the ATP 6 V 1 G 1 gene. This gene encodes a component of vacuolar ATPase V - ATPase
  • V - type proton ATPase subunit E 1 is an enzyme that in humans is encoded by the ATP 6 V 1 E 1 gene. This gene encodes a component of vacuolar ATPase V - ATPase
  • V - type proton ATPase subunit H is an enzyme that in humans is encoded by the ATP 6 V 1 H gene. This gene encodes a component of vacuolar ATPase V - ATPase
  • ATP6V1A, ATP6V1B1 ATP 6 V 1 B 2, ATP 6 V 1 C 1 ATP 6 V 1 C2, ATP 6 V 1 D, ATP 6 V 1 E 1 ATP 6 V 1 E2, ATP 6 V 1 F, ATP 6 V 1 G 1 ATP 6 V 1 G2, ATP 6 V 1 G3, ATP 6 V 1 H, ATP 6 V 0A 1 ATP 6 V 0A2, ATP 6 V 0A4
  • V - type proton ATPase subunit G 2 is an enzyme that in humans is encoded by the ATP 6 V 1 G2 gene. This gene encodes a component of vacuolar ATPase V - ATPase
  • V - type proton ATPase subunit D is an enzyme that in humans is encoded by the ATP 6 V 1 D gene. This gene encodes a component of vacuolar ATPase V - ATPase
  • V - type proton ATPase subunit C 2 is an enzyme that in humans is encoded by the ATP 6 V 1 C2 gene. This gene encodes a component of vacuolar ATPase V - ATPase