ⓘ SRPK1

                                     

ⓘ SRPK1

This gene encodes a serine/arginine protein kinase specific for the SR serine/arginine-rich domain family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. A second alternatively spliced transcript variant for this gene has been described, but its full length nature has not been determined.

SRPK1 allows angiogenesis, which is regulated by VEGF, which initiates or inhibits the formation of blood vessels, depending on alternative splicing.