ⓘ ORC2

                                     

ⓘ ORC2

The origin recognition complex ORC is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, ORC4, and ORC5. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication.

                                     
  • segregation with cytokinesis. ORC 6 has been shown to interact with MCM5, ORC2 Replication protein A1, ORC 4, DBF4, ORC 3, CDC45 - related protein, MCM4 and
  • protein have been reported. ORC 4 has been shown to interact with: MCM 2 MCM3, MCM4, MCM6, ORC 1, ORC2 ORC 3, ORC 5, and ORC 6. GRCh38: Ensembl release 89:
  • isoforms have been described. ORC 5 has been shown to interact with: MCM 2 MCM3, MCM4, MCM7, ORC 1, ORC2 ORC 3, and ORC 4. GRCh38: Ensembl release 89: ENSG00000164815
  • isoforms have been reported for this gene. ORC 3 has been shown to interact with: MCM4, MCM7, ORC2 ORC 4, ORC 5, and ORC 6. GRCh38: Ensembl release 89: ENSG00000135336
  • 7 - related protein kinase, Cyclin - dependent kinase 2 MCM 2 MCM4, MCM6, MCM7, MYST 2 ORC2 ORC 4, ORC 5, and SKP 2 GRCh38: Ensembl release 89: ENSG00000085840
  • An orc ɔːrk also spelled ork is a fictional humanoid creature akin to a goblin. Orcs were brought into modern usage by the fantasy writings of J.
  • replication. The subunits of this complex are encoded by the ORC 1, ORC2 ORC 3, ORC 4, ORC 5 and ORC 6 genes. ORC is a central component for eukaryotic DNA replication
  • The half - orc is a fictional creature born to mixed orc and human parentage in the Dungeons Dragons role - playing game. The half - orc is a playable race
  • Orcs Must Die 2 is a trap based action - tower defense video game that Robot Entertainment developed as the follow - up to the original Orcs Must Die with
  • Orc is a proper name for one of the characters in the complex mythology of William Blake. A fallen figure, Orc is the embodiment of rebellion, and stands
  • orcs are a primitive race of savage, bestial, barbaric humanoid. The orc was one of the earliest creatures introduced in the D D game. The D D orc is