ⓘ WNT5A

                                     

ⓘ WNT5A

The WNT gene family consists of structurally related genes that encode secreted signaling lipid modified glycoproteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. The WNT5A is highly expressed in the dermal papilla of depilated skin. It encodes a protein showing 98%, 98%, and 87% amino acid identity to the mouse, rat and the xenopus Wnt5a protein, respectively. Wnts, specifically Wnt5a, have also been positively correlated and implicated in inflammatory diseases such as rheumatoid arthritis, tuberculosis, and atherosclerosis. A central player and active secretor of Wnt5a in both cancer and these inflammatory diseases are macrophages. Experiments performed in Xenopus laevis embryos have identified that human frizzled-5 hFz5 is the receptor for the Wnt5a ligand and the Wnt5a/hFz5 signaling mediates axis induction. However, non-canonical Wnt5a has also been shown to bind to Ror1/2, RYK, and RTK depending on cell and receptor context to mediate a variety of functions ranging from cell proliferation, polarity, differentiation and apoptosis.

Gene Wnt5a is also a key component in the development of the rear of the female reproductive tract, development of uterine glands after birth, and the process of estrogen-mediated cellular and molecular response. Wnt5a is expressed throughout the endometrial stroma of the female reproductive tract of mammals and is essential in the development of education Mullerian rear of the neck of the uterus, tubes, vagina. In the absence of Wnt5a research conducted Mericskay et al. in mice and showed anterior Mullerian-derived structures of the oviducts and uterine horns can be easily identified, and rear derived structures of the uterus and vagina were absent indicating that this gene is essential for its development. Other members of the family VNT, which are necessary for the development of the reproductive tract, Wnt4 and Wnt7a. Failures in the development of the reproductive tract lead to infertility. Not only WNT5A Gene responsible for this education, but significate in the postnatal production of uterine glands otherwise known as adenogenesis, which is important for adult function. In addition to these two events Wnt5a is required for the entire process of estrogen-mediated cellular and molecular response.