ⓘ MTRR (gene)
Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cobalamin cofactor. Methionine synthase reductase regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP+ reductase FNR family of electron transferases.
Methionine synthase reductase MTRR primarily involved in reductive methylation of homocysteine to methionine using methylcobIalamin as an intermediate methyl carrier. Methionine is an essential amino acid, in mammals, is required for protein synthesis and one carbon metabolism. In its activated form, S-adenosylmethionine acts as methyl group donor in biological transmethylation reactions and the donor of Propylamine in the synthesis of polyamines. The main product of the demethylation of methionine is homocysteine. Remethylation of homocysteine occurs through the cobalamin dependent enzyme methionine synthase MTR. Linked folate cycle homocysteine metabolism via the MTR. Circulating blood folate 5-methyl tetrahydrofolate, 5-MTHF donor of methyl groups for metro to be used in cellular methylation. The cobalt methyl bond intermediate storage of methyl, methlycobIIIalamin cleaved heterolytically production of cobalamin in its highly reactive oxidation as cobIalamin. Enzyme linked cobIalamin a cofactor in enzyme functions of the MTR as a methyl carrier between 5-MTHF and homocysteine. CobIalamin oxidized to cobIIalamin approximately every 100 cycles of methyl transfer, providing cobIalamin-MTR enzyme inactive. Reactivation of this enzyme complex occurs through reductive remethylation by MTRR, using S-adenosylmethionine as a methyl donor. Reactivation of the metro can also be dependent on NADPH involving two redox proteins, soluble cytochrome B5 reductase and 1. However, this path is responsible for a minor role in reactivation, whereas MTRR remains one of the most important factors in the recovery of reactivation.
Biological processes under the influence of the MTRR include: sulfur amino acid metabolic process, DNA methylation, methionine metabolism, biosynthesis, methionine, methylation, S-adenosyl methionine cycle, homocysteine catabolic process, folic acid metabolism, redox processes and negative regulation of cystathionine beta-synthases.
- MTRR may refer to: 5 - methyltetrahydrofolate - homocysteine methyltransferase reductase, a human gene Memory Type Range Registers, in computer hardware
- vanillate demethylase and others. Human genes encoding proteins containing this domain include: CYB5R1 CYB5R2 CYB5R4 MTRR NDOR1 NOS1 NOS2A NOS3 OXNAD1
- the simultaneous detection of C677T and A1298C polymorphisms with the A66G MTRR polymorphism in a single PCR reaction. Severe MTHFR deficiency is rare about
- 3 - - glycoprotein beta - 1, 2 - N - acetylglucosaminyltransferase MIR146A: microRNA 146a MTRR 5 - methyltetrahydrofolate - homocysteine methyltransferase reductase MZB1:
- Makarova, and T. V. Nasedkina 2008 Genetic Polymorphism of GST, NAT2, and MTRR and Susceptibility to Childhood Acute Leukemia Molecular Biology 42, 187 - 197
- hereditary hyperhomocysteinemia. Genetic defects that affect the MTHFR, MTR, and MTRR MS enzyme pathways can also contribute to high homocysteine levels. Inborn