ⓘ MAP3K8

                                     

ⓘ MAP3K8

This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the ERK1/2 and p38 MAP kinases. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 NFKB1. This gene may also start transcription at a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. In mice, this gene is known as Tpl2 and it is a tumor suppressor gene whose absence contributes to the development and progression of cancer.

                                     
  • aka TAK1 MAP3K8 aka TPL2 or Tpl2 MAP 3 K 9 MAP 3 K 10 MAP 3 K 11 aka MEKK11 aka MLK 3 MAP 3 K 12 aka MUK MAP 3 K 13 aka LZK MAP 3 K 14 MAP 3 K 15 MAP 3 K 16 aka TAO1
  • kinase kinase 3 is an enzyme that in humans is encoded by the MAP 3 K 3 gene, which is located on the long arm of chromosome 17 17q23. 3 This gene product
  • and activate MAPK 8 JNK, MAP 2 K 7 MKK7, which suggests a role in the JNK signaling pathway. MAP 3 K 13 has been shown to interact with PRDX 3 GRCh38: Ensembl
  • MAP 3 K 7P1 TAB1 and MAP 3 K 7P2 TAB2 this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK 8 JNK, MAP 2K4 MKK4
  • protein kinase kinase kinase 9 is an enzyme that in humans is encoded by the MAP 3 K 9 gene. GRCh38: Ensembl release 89: ENSG00000006432 - Ensembl, May 2017 GRCm38:
  • the MAP 3 K 11 gene. The protein encoded by this gene is called MLK 3 and it is a member of the serine threonine kinase family. This kinase contains a SH 3 domain
  • the MAP 3 K 10 gene. The protein encoded by this gene is a member of the serine threonine kinase family. This kinase has been shown to activate MAPK 8 JNK
  • involvement in a regulated signaling process. MAP 3 K 2 has been shown to interact with: MAP 2 K 5, MAP 2 K 7, MAPK 8 SH2D2A, and XIAP GRCh38: Ensembl release 89:
  • acid induced neuronal differentiation. MAP 3 K 12 has been shown to interact with MAPK 8 IP1, MAP 2 K 7 and MAPK 8 IP2. MAP 3 K 12, otherwise known as DLK, can initiate
  • kinase kinase kinase 1 is an enzyme that in humans is encoded by the MAP 3 K 1 gene. MAP 3 K or MEK kinase or Raf, is a serine threonine kinase that occupies