ⓘ Glypican 3

                                     

ⓘ Glypican 3

Glypican-3 is a protein that, in humans, is encoded by the GPC3 gene. The GPC3 gene is located on human X chromosome where the most common gene encodes a 70-kDa core protein with 580 amino acids. Three variants have been detected that encode alternatively spliced forms termed Isoforms 1, Isoform 3 and Isoform 4.

                                     
  • Glypicans constitute one of the two major families of heparan sulfate proteoglycans, with the other major family being syndecans. Six glypicans have been
  • Glypican - 4 is a protein that in humans is encoded by the GPC4 gene. Cell surface heparan sulfate proteoglycans are composed of a membrane - associated protein
  • Glypican - 1 is a protein that in humans is encoded by the GPC1 gene. Cell surface heparan sulfate proteoglycans are composed of a membrane - associated protein
  • Glypican - 6 is a protein that in humans is encoded by the GPC6 gene. The glypicans comprise a family of glycosylphosphatidylinositol - anchored heparan sulfate
  • Glypican - 5 is a protein that in humans is encoded by the GPC5 gene. Cell surface heparan sulfate proteoglycans are composed of a membrane - associated protein
  • Glypican 2 GPC2 also known cerebroglycan, is a protein which in humans is encoded by the GPC2 gene. Cerebroglycan is a glycophosphatidylinositol - linked
  • researchers expressed doubt regarding the involvement of PTEN or GPC 3 which codes for glypican 3 and may play a role in regulating cell division and growth regulation
  • glycosylphosphatidylinositol GPI anchored glypicans Other minor forms of membrane HSPG include betaglycan and the V - 3 isoform of CD44 present on keratinocytes
  • been identified, one cause of SGBS type I is a mutation of the glypican - 3 gene GPC 3 on the X chromosome locus q26.1. This particular gene is widely
  • stabilizers Dally and glypican 3 GPC 3 which inhibit diffusion. In cancer cells, both the heparan sulfate chains and the core protein of GPC 3 are involved in
  • Pastan I, Ho M May 2017 Construction of an immunotoxin, HN 3 - mPE24, targeting glypican - 3 for liver cancer therapy Oncotarget. 8 20 32450 32460.
  • Sandal S, Filmus J 2006 Processing by convertases is not required for glypican - 3 - induced stimulation of hepatocellular carcinoma growth J. Biol. Chem