ⓘ MARCKS

                                     

ⓘ MARCKS

Myristoylated alanine-rich C-kinase substrate is a protein that in humans is encoded by the MARCKS gene. It plays important roles in cell shape, cell motility, secretion, transmembrane transport, regulation of the cell cycle, and neural development. Recently, MARCKS has been implicated in the exocytosis of a number of vesicles and granules such as mucin and chromaffin. It is also the name of a protein family, of which MARCKS is the most studied member. They are intrinsically disordered proteins, with an acidic pH, with high proportions of alanine, glycine, proline, and glutamic acid. They are membrane-bound through a lipid anchor at the N-terminus, and a polybasic domain in the middle. They are regulated by Ca 2+ /calmodulin and protein kinase C. In their unphosphorylated form, they bind to actin filaments, causing them to crosslink, and sequester acidic membrane phospholipids such as PIP2.

The protein encoded by this gene is a substrate for protein kinase C. it is localized on the plasma membrane and is an actin filament crosslinking protein. Phosphorylation of protein kinase C or binding to calcium-calmodulin inhibits its Association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.

                                     
  • Marcks is a surname. Notable people with the surname include: Erich Marcks 1891 1944 German general Gerhard Marcks 1889 1981 German sculptor Greg
  • The Gerhard Marcks Museum or Gerhard Marcks House German: Gerhard Marcks Haus is a museum in Bremen, Germany, inspired by the work of the sculptor and
  • Corps in 1917. Marcks was awarded the Iron Cross 2nd Class and then 1st Class, and posted to the German Supreme Command. After the war, Marcks fought with
  • in Weimar, Marcks was one of the first three faculty members to be hired, along with Feininger and Johannes Itten. Specifically, Marcks was appointed
  • eight and with Marcks in the three seat, they rowed to a sixth place finish. In 1995 in their fifth year of rowing together Slatter and Marcks stepped into
  • La Marck German: von der Mar c k was a noble family, which from about 1200 appeared as the counts of Mark. The family history started with Count Adolf
  • Marcks born August 12, 1976 is an American director and screenwriter of motion pictures who lives in Silver Lake, Los Angeles, California. Marcks grew
  • Adolph III of the Marck German: Adolf III von der Mark c. 1334 7 September 1394 was the Bishop of Munster as Adolph from 1357 until 1363, the
  • Marcks Family Miniature Circus is a miniature representation of the Sells Floto Circus of the 1930s. It was conceived and originated by Isaac Marcks and