ⓘ Syncytin-1

                                     

ⓘ Syncytin-1

Syncytin-1 also known as enverin is a protein found in humans and other primates that is encoded by the ERVW-1 gene. Syncytin-1 is a cell-cell fusion protein whose function is best characterized in placental development. The placenta in turn aids in embryo attachment to the uterus and establishment of a nutrient supply.

The gene encoding this protein is an endogenous retroviral element, which is a remnant of ancient retroviral infections integrated into the germ line of primates. In the case of syncytin-1, this integration probably occurred more than 25 million years ago. Syncytin-1 is one of two known protein syncytin is expressed in catarrhini primates other syncytin-2 and one of the many syncytins captured and domesticated many times in the course of evolutionary time in different species of mammals. This is similar to the inclusion of certain types of bacteria into eukaryotic cells during evolution, which eventually turned into mitochondria.

ERVW-1 is ERVWE1 full-length provirus on chromosome 7 at locus 7q21.2 surrounded by long terminal repeats liters and is preceded by a gag group antigen ERVW1 and gender POLmerase in provirus that contain nonsense mutations making them non-coding.

Syncytin-1 is also involved in several neurological disorders, particularly multiple sclerosis, as the immunogen.

                                     
  • Examples include: SNARE protein such as VAMP HERV Syncytins such as Syncytin - 1 and Syncytin - 2 Gp41 Interbilayer forces in membrane fusion Viral membrane
  • Syncytin - 2 also known as endogenous retrovirus group FRD member 1 is a protein that in humans is encoded by the ERVFRD - 1 gene. This protein plays a key
  • Kudo Y, Boyd CA August 2002 Changes in expression and function of syncytin and its receptor, amino acid transport system B 0 ASCT2 in human placental
  • HERV - W s main gene expression is ERVWE - 1 which is a highly fusogenic env glycoprotein also called syncytin - 1 because it induces the formation of syncytia
  • evidence for a functional role. Similar endogenous retroviral Env genes like syncytin - 1 have important roles in placental formation and embryonic development
  • HIV, and Ebola during infection. This class of fusogens also includes syncytins which are utilized in mammalian cell fusions. In contrast to Class I fusogens
  • without a shelled egg. This is possible thanks to key proteins called syncytins which allow exchanges between the mother and its offspring through a
  • called syncytin and is encoded by an endogenous retrovirus called ERVWE 1 on chromosome seven. Remarkably, the capture of syncytin or syncytin - like genes
  • PMID 11071865. Yu C, Shen K, Lin M, et al. 2003 GCMa regulates the syncytin - mediated trophoblastic fusion J. Biol. Chem. 277 51 50062 8. doi: 10
  • fusion of underlying cytotrophoblast cells. This fusion is assisted by syncytin a protein that was integrated into mammalian genomes from an endogenous
  • viruses would require the help and function of viral accessory proteins. Syncytin is an endogenous retrovirus protein that has been captured in the mammalian
  • regulation of the expression of syncytin HERV - W maternally imprinted PEG10, and SGCE in human placenta Biol. Reprod. 69 1 286 93. doi: 10.1095 biolreprod