ⓘ DKK1

                                     

ⓘ DKK1

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the Wnt signaling pathway. Dickkopf WNT signaling pathway inhibitor 1 Dkk1 is a protein-coding gene that acts from the anterior visceral endoderm. The dickkopf protein encoded by DKK1 is an antagonist of the Wnt/β-catenin signalling pathway that acts by isolating the LRP6 co-receptor so that it cannot aid in activating the WNT signaling pathway. DKK1 was also demonstrated to antagonize the Wnt/β-catenin pathway via a reduction in β-catenin and an increase in OCT4 expression. This inhibition plays a key role in heart, head and forelimb development during anterior morphogenesis of the embryo.

                                     
  • acid vitamin C One study suggested that because l - threonate inhibits DKK1 expression in vitro, it may have potential in treatment of androgenic alopecia
  • ligands Dickkopf 1 Dickkopf2, Dickkopf3, Dickkopf4, EpCAM and Rspondin 1 This gene encodes a high - affinity dickkopf homolog 1 DKK1 transmembrane receptor
  • Dickkopf - related protein 3 is a protein that in humans is encoded by the DKK 3 gene. This gene encodes a protein that is a member of the dickkopf family
  • are insulin - like growth factor - 1 cytokines e.g., colony stimulating factor 2 WNT regulatory proteins i.e., DKK1 and members of the transforming
  • mediated downregulation of DKK1 appears to make lung cancer cells easier to kill, suggesting that cancer cells upregulate DKK1 for their own survival and
  • Dickkopf - related protein 2 is a protein that in humans is encoded by the DKK 2 gene. This gene encodes a protein that is a member of the dickkopf family
  • were Russia 1 907 million DKK the United States 898 million DKK the United Kingdom 851 million DKK and Denmark 697 million DKK European Union
  • by the increasing concentrations of Cerebrus, DKK1 and Nodal around day 7 - 9 in the mouse embryo. Lim - 1 contributes to the formation of the anterior portion
  • the ISS name 1973 Overseas expansion started 1975 Group revenue reached DKK 1 billion 1977 ISS shares listed on the Copenhagen Stock Exchange 1989 The