ⓘ Optineurin

                                     

ⓘ Optineurin

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

                                     
  • Variant of Optineurin M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin PLoS
  • OPTN may refer to: Optineurin Organ Procurement and Transplantation Network, operated by the United Network for Organ Sharing, which facilitates organ
  • through the attachment of Ubiquitin and finally the phosphorylating protein optineurin binds to them. This tags them for special cell organelles, the autophagosomes