ⓘ TNFAIP3

                                     

ⓘ TNFAIP3

Tumor necrosis factor, alpha-induced protein 3 or A20 is a protein that in humans is encoded by the TNFAIP3 gene.

This gene was identified as the gene expression which is rapidly induced by the tumor necrosis factor TNF. The protein encoded by this gene is a zinc finger protein and a deubiquitinating enzyme and inhibits factor NF-Kappa B activation and TNF-mediated apoptosis. A20 is an ancient protein, and homologue protein can be found as cnidaria with conserved domain protein composition. Using a knockout mouse TNFAIP3 and its transcriptional repressor, that is, KCHIP3, TNFAIP3, have been shown to be critical for limiting inflammation by terminating endotoxin and TNF-induced factor NF-Kappa B responses. In short, the deubiquitinase function of TNFAIP3 has been shown to remove ubiquitin chains from ve-cadherin to prevent the loss of ve-cadherin in endothelial adherens connection.