ⓘ ERCC6

                                     

ⓘ ERCC6

DNA excision repair protein ERCC-6 is a protein that in humans is encoded by the ERCC6 gene. The ERCC6 gene is located on the long arm of chromosome 10 at position 11.23.

Having 1 or more copies of a mutated ERCC6 causes Cockayne syndrome, type II.

                                     
  • gene. CS arises from germline mutations in either of two genes CSA ERCC 8 or CSB ERCC6 CSA mutations generally give rise to a more moderate form of CS
  • genes: ERCC1, ERCC2, ERCC3, ERCC 4, ERCC 5, ERCC6 and ERCC 8. Members 1 though 5 are associated with Xeroderma Pigmentosum. Members 6 and 8 are associated with
  • ERCC excision repair 6 like, spindle assembly checkpoint helicase is a protein that in humans is encoded by the ERCC 6 L gene. This gene encodes a member
  • ERCC 4 is a protein designated as DNA repair endonuclease XPF that in humans is encoded by the ERCC 4 gene. Together with ERCC 1, ERCC 4 forms the ERCC 1 - XPF
  • excision repair protein ERCC - 1 is a protein that in humans is encoded by the ERCC 1 gene. Together with ERCC 4, ERCC 1 forms the ERCC 1 - XPF enzyme complex that
  • ERCC 2, or XPD is a protein involved in transcription - coupled nucleotide excision repair. The XPD ERCC 2 gene encodes for a 2.3 - kb mRNA containing 22 exons
  • protein complementing XP - G cells is a protein that in humans is encoded by the ERCC 5 gene. Excision repair cross - complementing rodent repair deficiency, complementation
  • proteins include ERCC 1 ERCC 1 ERCC 2 XPD ERCC 3 XPB ERCC 4 XPF ERCC 5 XPG ERCC6 CSB and ERCC 8 CSA DNA repair - deficient ERCC 1 mutant mice show
  • has been shown to unwind DNA with 3 - 5 polarity. The function of the XPB ERCC 3 protein in NER is to assist in unwinding the DNA double helix after damage
  • CP, Sancar A Jan 1997 Human transcription - repair coupling factor CSB ERCC6 is a DNA - stimulated ATPase but is not a helicase and does not disrupt the
  • gene lesion involves a mutation in the CSB gene. It can be associated with ERCC6 Xeroderma pigmentosum List of cutaneous conditions RESERVED, INSERM US14
  • employed in DNA repair. The XPF ERCC 4 protein together with the ERCC 1 protein forms a complex usually designated ERCC 1 - XPF. This complex separates the