ⓘ WASL (gene)

                                     

ⓘ WASL (gene)

Neural Wiskott-Aldrich syndrome protein is a protein that in humans is encoded by the WASL gene.

Syndrome Wiskott-Aldrich had a family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of many different motifs suggests that they are regulated by different stimuli, and interact with multiple proteins. Recent studies have shown that these proteins directly or indirectly associated with small GTP-Aza, Cdc42 is known to regulate the formation of actin filaments and organization of the cytoskeleton complex Arp2 / 3. The Wasl gene product, but the homolog was protein, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.

According to one study, mouse DAB1 regulates actin cytoskeleton through N-Wasp.

Diseases associated with Wasl include Wiskottt-Aldrich and ospowiki.

                                     
  • WASL may refer to: WASL FM a radio station 100.1 FM licensed to Dyersburg, Tennessee, United States WASL gene a human gene called Wiskott - Aldrich
  • WAS WASL - interacting protein family member 2 is a protein that in humans is encoded by the WIPF2 gene This gene encodes a WASP interacting protein WIP - related
  • WAS WASL - interacting protein family member 1 WIP is a protein that in humans is encoded by the WIPF1 gene This gene encodes a protein that plays an
  • interact with: FMNL1, MLLT4 Vasodilator - stimulated phosphoprotein, WASF1, and WASL GRCh38: Ensembl release 89: ENSG00000108518 - Ensembl, May 2017 GRCm38:
  • melanocytic cells RHOQ gene expression may be regulated by MITF. RHOQ has been shown to interact with EXOC7, GOPC, PARD6B, WASL CDC42EP2, TRIP10 and CDC42EP3
  • has been shown to interact with: ACTR3 ARPC2, CTNND1, FER, KCNA2, SHANK2, WASL and WIPF1. actin gelsolin transferrin villin ENSG00000288401 GRCh38: Ensembl
  • NEDD9, PAK1, PDGFRB, PKN2, PTK2, RASA1, RICS, RRAS, SOCS7, SOS1, TBK1, WASL WIPF1, and WAS. Signal transducing adaptor protein Receptor tyrosine kinase
  • INF2, JMY LMOD1, LMOD2, LMOD3 MTSS1, PXK WAS, WASF1, WASF2, WASF3, WASF4, WASL WASPIP, WHDC1, WIPF1, WIPF2 PDB: 2d1k Lee SH, Kerff F, Chereau D, Ferron
  • Statistics download files www.genenames.org. HUGO Gene Nomenclature Committee. 27 January 2020. Retrieved 27 January 2020.