ⓘ PIM1

                                     

ⓘ PIM1

Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene.

PIM-1 is a proto-oncogene that encodes a serine / threonine kinase of the same name. The PIM-1 oncogene was first described in relation to murine T-cell lymphomas, as it is most often the locus of activation of the virus leukemia mice Moloney. Subsequently, the oncogene has been implicated in several human Cancers, including prostate cancer, acute myeloid leukemia and other hematopoietic malignancies. Is expressed mainly in spleen, thymus, bone marrow, prostate, oral epithelium, hippocampus and fetal liver cells, PIM-1 has also been found to be expressed in cultures of human cells isolated from the tumor. PIM-1 is mainly involved in the progression of the cell cycle, apoptosis and activation of transcription, as well as more General signal transduction.

                                     
  • shares 55 sequence identity with PIM1 and the structure of PIM 2 is quite closely related to PIM1 Like PIM1 PIM 2 shows a bi - lobal kinase architecture
  • coli serine proteinase La, gene lon protease, gene lon proteins, PIM1 protease, PIM1 proteinase, serine protease La is an enzyme. This enzyme catalyses
  • protease gene that can partially complement a yeast pim1 - deletion mutant Plant Mol. Biol. 37 1 141 54. doi: 10.1023 A: 1005912831051. PMID 9620272
  • Jakartans by its acronym: PIM complex: is actually three large malls, the older 3 - storey PIM1 and the newer 5 - storey PIM 2, interconnected via a two
  • The Bartizan of Porto Pim Portuguese: Torre de Vigia do Porto Pim Guarita of Porto Pim is a medieval watchtower located in the civil parish of Angustias
  • coiled - coil domain at its C terminus and a PX domain at its N terminus. Binding to PIM1 causes translocation to the nucleus. SNX6 has been shown to associate with
  • Admiral Bedford Clapperton Trevelyan Pim RN, MP, FRGS 12 June 1826 30 September 1886 was a Royal Navy officer, Arctic explorer, barrister, and author
  • Commerce. Joshua Pim was born in 1748, the son of John Joshua Pim 1718 - 1797 Joshua and Joseph and traded as Joshua and Joseph Pim of Usher s Island
  • Pim Ligthart born 16 June 1988 in Hoorn is a Dutch professional road bicycle racer, who currently rides for UCI ProTeam Total Direct Energie. Ligthart