ⓘ MAD2L1

                                     

ⓘ MAD2L1

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.

                                     
  • MAD2L1 - binding protein is a protein that in humans is encoded by the MAD 2 L 1 BP gene. The protein encoded by this gene was identified as a binding protein
  • at the metaphase plate. MAD 2 L 2 is a homolog of MAD2L1 MAD 2 L 2 has been shown to interact with: ADAM9, MAD2L1 REV 1 and REV3 L GRCh38: Ensembl release
  • have been found for this gene. MAD 1 L 1 has been shown to interact with: HDAC 1 Histone deacetylase 2 and MAD2L1 MAD 1 MAD 2 Hyperphosphorylation GRCh38:
  • confer sensitivity to microtubule poisons. The human orthologues of Mad 2 MAD2L1 and MAD 2 L 2 were first cloned in a search for human cDNAs that would rescue
  • and MAD2L1 Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA 2 Phosphorylates: PPP 1 CC
  • The MADS box is a conserved sequence motif. The genes which contain this motif are called the MADS - box gene family. The MADS box encodes the DNA - binding
  • anaphase inhibitor Mad 2 to unattached kinetochores and is essential for Mad 2 - Cdc20 complex formation in vivo but not in vitro. In vivo, Mad 1 acts as a competitive
  • erythroid 2 - related factor 1 Nrf 1 also known as nuclear factor erythroid - 2 - like 1 NFE 2 L 1 is a protein that in humans is encoded by the NFE 2 L 1 gene. Since
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  • expression of BubR 1 in mice extends a healthy lifespan. BUB 1 B has been shown to interact with: AP 2 B 1 BRCA 2 BUB3, CDC20, HDAC 1 MAD2L1 and SNCG. GRCh38: