ⓘ GADD45A

                                     

ⓘ GADD45A

This gene is a member of a group of genes, the GADD45 genes, whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents mutagens. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase.

                                     
  • Xenopus homolog of GADD 45 G in embryonic development. It plays a large role in neural and brain development with GADD45A GADD 45 G and GADD45A knockdowns are
  • Arrest and DNA Damage or gadd 45 genes, including GADD45A originally termed gadd 45 GADD 45 B originally termed MyD118 and GADD 45 G originally termed CR6
  • Lung FD, Roller PP, Fornace AJ Oct 2001 Oligomerization of human Gadd45a protein The Journal of Biological Chemistry. 276 42 39330 9. doi: 10
  • failure and marked neurodegeneration. GADD 45 GIP1 has been shown to interact with GADD 45 G, GADD 45 B and GADD45A GRCh38: Ensembl release 89: ENSG00000179271
  • have been described. MAP3K4 has been shown to interact with GADD 45 G, GADD 45 B and GADD45A GRCh38: Ensembl release 89: ENSG00000085511 - Ensembl, May 2017
  • first known DNA - damage - inducible genes. This included the GADD45A gene and other members of the GADD growth - arrest and DNA - damage inducible group. His laboratory
  • inhibitor 1C, DNMT1, EP300, Flap structure - specific endonuclease 1, GADD45A GADD 45 G, HDAC1, HUS1, ING1, KCTD13, KIAA0101, Ku70, Ku80, MCL1, MSH3, MSH6
  • protein GADD 34 is a protein that in humans is encoded by the PPP1R15A gene. The Gadd 34 MyD116 gene was originally discovered as a member in a set of gadd and
  • has been shown to interact with: BCL2, CCNB1, CCNE1, CDKN3 DAB2, FANCC, GADD45A LATS1, LYN, P53, and UBC. E2F E2F.2FpRb complexes Hyperphosphorylation
  • expression. Demethylation appears to occur by a DNA repair process involving the GADD 45 G protein. Activation of Immediate Early Genes by Drugs of Abuse a monograph