ⓘ MAP3K1

                                     

ⓘ MAP3K1

MAP3K1 or MEKK1 is a serine/threonine kinase that performs a pivotal role in a network of phosphorylating kinase enzymes integrating cellular receptor responses to a number of mitogenic and metabolic stimuli, including: TNF receptor superfamily TNFRs, T-cell receptor TCR, Epidermal growth factor receptor EGFR, and TGF beta receptor TGFβR. Mitogen-activated protein kinase kinases MAP2Ks are substrates for direct phosphorylation by the MAP3K1 protein kinase. Mouse genetics has revealed that MAP3K1 is important in embryonic development, cell growth, cell migration, cytokine production and B cell antibody production. MAP3K1 has been identified by GWAS in breast cancer