ⓘ ADD1

                                     

ⓘ ADD1

Alpha-adducin is a protein that in humans is encoded by the ADD1 gene.

Adducins are a family of cytoskeleton proteins encoded by three genes. Adducin is a heterodimeric protein that consists of related subunits, which are made from certain genes, but have a similar structure. Alpha - and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha - and gamma-adducins are ubiquitously expressed. In contrast to the beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca2 /calmodulin and is a substrate for protein kinases a and C. alternative splicing results in multiple variants encoding different isoforms, however, not all variants have been described. Add 1 polymorphism is associated with hypertension.