ⓘ BTRC (gene)

                                     

ⓘ BTRC (gene)

F-box/WD repeat-containing protein 1A also known as βTrCP1 or Fbxw1 or hsSlimb or pIkappaBalpha-E3 receptor subunit is a protein that in humans is encoded by the BTRC gene.

This gene encodes a member of f-box family protein, which is characterized by an approximately 40 residue structural motif, the f-box. F-box proteins are one of four subunits of ubiquitinilated protein complex called the SCF, Skp1-Cul1-f-box protein, which is often, but not always, recognize substrates in a phosphorylation-dependent manner. F-box proteins are divided into 3 classes:

  • And Fbxos containing either "other" protein–protein interaction modules or no recognizable motifs.
  • Fbxls containing leucine-rich repeats.
  • Fbxws containing WD40 repeats.

The protein encoded by this gene belongs to the class as Fbxw, in addition to the f-box, this protein contains multiple WD 40 repeats. This protein is homologous to the Xenopus ßTrCP, yeast Met30, neurospora Scon2 and from Drosophila Slimb. In mammals, in addition to ßTrCP1 in paralog protein called ßTrCP2 or FBXW11 also exists, but, yet, their functions appear redundant and indistinguishable.

                                     
  • BTRC may refer to: Bangladesh Telecommunication Regulatory Commission, an independent commission of Bangladesh Government Beta - transducin repeat containing
  • 2 - deoxy - scyllo - inosose synthase EC 4.2.3.124, btrC gene neoC gene kanC gene is an enzyme with systematic name D - glucose - 6 - phosphate phosphate - lyase
  • transcriptional programs by regulating the NF - kappaB and the WNT pathways. BTRC gene has been shown to interact with: FBXW11 DLG1 IκBα NFKB2 RELA SKP1A CDC34
  • initiation of DNA replication. CDC34 has been shown to interact with CSNK2B, BTRC and CDK9. GRCh38: Ensembl release 89: ENSG00000099804 - Ensembl, May 2017
  • disease called DAVID s disease. NFKB2 has been shown to interact with: BCL3, BTRC MAP3K8, NFKB1, NFKBIE, RELA, RELB, REL, and TSC22D3. NF - κB GRCh38: Ensembl
  • malignant state of these tumor cells. IκBα has been shown to interact with: BTRC C22orf25, CHUK, DYNLL1, G3BP2, Heterogeneous nuclear ribonucleoprotein A1
  • interact with NFKB1, RELA, RELB, BTRC RPS27A, BCL3, MAP3K8, NFKBIA, SIN3A, SUMO1, Tat. Mutations in the TANGO2 gene may cause defects in mitochondrial
  • manner. RELA has been shown to interact with: APBA2, AHR, ASCC3, BRCA1, BTRC c - Fos, c - Jun, C22orf25, CDK9, CEBPB, CEBPE, CREBBP, CSNK2A1, CSNK2A2, DHX9
  • this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. SKP1A has been shown to interact with: BTRC CACYBP
  • to have protein - protein interactions with the following and more. FUT11 BTRC NAGA NID2 ANKRD46 VWDE ITGA8 The protein was discovered in 1996 by Italian