ⓘ PSMB8

                                     

ⓘ PSMB8

Proteasome subunit beta type-8 as known as 20S proteasome subunit beta-5i is a protein that in humans is encoded by the PSMB8 gene. This protein is one of the 17 essential subunits that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-5, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "Chymotrypsin-like" activity and is capable of cleaving after large hydrophobic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. The constitutive subunit beta1, beta2, and beta 5 can be replaced by their inducible counterparts beta1i, 2i, and 5i when cells are under the treatment of interferon-γ. The resulting proteasome complex becomes the so-called immunoproteasome. An essential function of the modified proteasome complex, the immunoproteasome, is the processing of numerous MHC class-I restricted T cell epitopes.

                                     
  • PSMB8 antisense RNA 1 head to head is a protein that in humans is encoded by the PSMB8 - AS1 gene. ENSG00000235540, ENSG00000234365, ENSG00000233089, ENSG00000233140
  • symptoms. The current known cause for the disorder is a mutation in the PSMB8 gene or mutations in other closely related genes. The syndrome was first
  • regards to oncology, PSMB 9 in conjunction with other genes that are involved with immune response processes TAP1, PSMB8 PSMB 9, HLA - DQB1, HLA - DQB2
  • class I MHC peptides. The human PSMB 7 gene has 8 exons and locates at chromosome band 9q34.11 - q34.12. The gene PSMB 7 encodes a member of the proteasome
  • on systematic nomenclature is a protein that in humans is encoded by the PSMB 4 gene. This protein is one of the 17 essential subunits alpha subunits 1 7
  • on systematic nomenclature is a protein that in humans is encoded by the PSMB 6 gene. This protein is one of the 17 essential subunits alpha subunits 1 - 7
  • on systematic nomenclature is a protein that in humans is encoded by the PSMB 2 gene. This protein is one of the 17 essential subunits alpha subunits 1 7
  • on systematic nomenclature is a protein that in humans is encoded by the PSMB 1 gene. This protein is one of the 17 essential subunits alpha subunits 1 - 7
  • proteasome subunit beta - 5 is a protein that in humans is encoded by the PSMB 5 gene. This protein is one of the 17 essential subunits alpha subunits 1 7
  • immunoproteasome. The human PSMB 10 gene has 8 exons and locates at chromosome band 16q22.1. The human protein proteasome subunit beta type - 8 is 25 kDa in size and
  • proteasome subunit beta - 3, is a protein that in humans is encoded by the PSMB 3 gene. This protein is one of the 17 essential subunits that contribute to