ⓘ CYP3A5

                                     

ⓘ CYP3A5

CYP3A5 encodes a member of the cytochrome P450 superfamily of enzymes. Like most of the Cytochrome P450, the CYP3A5 is expressed in the prostate and the liver. It is also expressed in epithelium of the small intestine and large intestine for uptake and in small amounts in the bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary at protein level.

                                     
  • The CYP 3 A cluster consists of four genes: CYP 3 A4, CYP3A5 CYP 3 A7, and CYP 3 A43. The region also contains four pseudogenes: CYP 3 A51P, CYP 3 A52P, CYP 3 A54P
  • mechanisms such as CYP3A5 or CYP 3 A7 compensation for lowered levels of CYP 3 A4 that affect drug clearance in both men and women. CYP 3 A4 substrate activation
  • regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans Pharmacogenetics. 10 5 415 24. doi: 10
  • Robbins GK, Clifford D, Haas DW September 2010 Effect of CYP 2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response:
  • used as a probe for CYP 2A6 activity. The CYP 2A6 gene is part of a large cluster of cytochrome P450 genes from the CYP 2A, CYP 2B and CYP 2F subfamilies on chromosome
  • Cytochrome P450 3 A43 is a protein that in humans is encoded by the CYP 3 A43 gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes
  • Cytochromes P450 CYPs are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize
  • studies, the substance is used as an inhibitor of the liver enzymes CYP 3 A4 and CYP3A5 Stresser, D. M. Broudy, M. I. Ho, T Cargill, C. E. Blanchard
  • Cytochrome P450 2D6 CYP 2D6 is an enzyme that in humans is encoded by the CYP 2D6 gene. CYP 2D6 is primarily expressed in the liver. It is also highly expressed
  • Cytochrome P450 2C9 abbreviated CYP 2C9 is an enzyme that in humans is encoded by the CYP 2C9 gene. CYP 2C9 is an important cytochrome P450 enzyme with
  • enzyme that in humans is encoded by the CYP 4F 3 gene. CYP 4F 3 encodes two distinct enzymes, CYP 4F 3 A and CYP 4F 3 B, which originate from the alternative splicing
  • subfamily A member 1 abbreviated CYP 24A1 is a member of the cytochrome P450 superfamily of enzymes encoded by the CYP 24A1 gene. It is a mitochondrial