ⓘ Thyrotoxic myopathy

                                     

ⓘ Thyrotoxic myopathy

Thyrotoxic myopathy is a neuromuscular disorder that develops due to the overproduction of the thyroid hormone thyroxine. Also known as hyperthyroid myopathy, TM is one of many myopathies that lead to muscle weakness and muscle tissue breakdown. Evidence indicates the onset may be caused by hyperthyroidism. There are two known causes of hyperthyroidism that lead to development thyrotoxic myopathy including a multinodular goiter and Graves disease. Physical symptoms of TM may include muscle weakness, the breakdown of muscle tissue, fatigue, and heat intolerance. Physical acts such as lifting objects and climbing stairs may become increasingly difficult. If untreated, TM can be an extremely debilitating disorder that can, in extreme rare cases, lead to death. If diagnosed and treated properly the effects can be controlled and in most cases reversed leaving no lasting effects.

                                     
  • myxedema Thyroid disease may also cause muscle weakness in the form of thyrotoxic myopathy but this is constant rather than episodic. Genetic mutations in
  • indicate a myositis, and abnormal thyroid function tests may indicate thyrotoxic myopathy Antibodies against voltage - gated calcium channels can be identified
  • paralysis can also be caused by hyperthyroidism, and are then labeled thyrotoxic periodic paralysis however, if this is the underlying condition there
  • disease, the signs and symptoms are persistent and increasing and include myopathy The inflammation and edema of the extraocular muscles lead to gaze abnormalities