ⓘ Metabotropic glutamate receptor 6

                                     

ⓘ Metabotropic glutamate receptor 6

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

mGluR6 specifically expressed in the retina, in a subtype of bipolar cells, depolarization in response to light, known as bipolar cells. These cells form synapses with photoreceptor cells, and to detect the neurotransmitter glutamate via the GPCR signal transduction cascade. The glutamate receptor mGluR6 is post-synaptic to the tips of the dendrites of bipolar cells and initiates a signaling cascade. In human patients, mutations in the GRM6 gene are associated with congenital stationary night blindness.

                                     
  • The metabotropic glutamate receptors or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic process. They are members
  • Ionotropic glutamate receptors iGluRs form the ion channel pore that activates when glutamate binds to the receptor Metabotropic glutamate receptors mGluRs
  • Metabotropic glutamate receptor 7 is a protein that in humans is encoded by the GRM7 gene. L - glutamate is the major excitatory neurotransmitter in the
  • Metabotropic glutamate receptor 8 is a protein that in humans is encoded by the GRM8 gene. L - glutamate is the major excitatory neurotransmitter in the
  • Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene. Together with GRM 6 GRM7 and GRM8 it belongs to group III of
  • The glutamate receptor metabotropic 1, also known as GRM1, is a human gene which encodes the metabotropic glutamate receptor 1 mGluR1 protein. L - glutamate
  • Metabotropic glutamate receptor 2 mGluR2 is a protein that, in humans, is encoded by the GRM2 gene. mGluR2 is a G protein - coupled receptor GPCR that
  • Metabotropic glutamate receptor 5 is a G protein - coupled receptor that in humans is encoded by the GRM5 gene. The amino acid L - glutamate is the major excitatory
  • Metabotropic glutamate receptor 3 mGluR3 is a protein that, in humans, is encoded by the GRM3 gene. In humans, mGluR3 is encoded by the GRM3 gene on
  • class of receptors includes the metabotropic glutamate receptors muscarinic acetylcholine receptors GABAB receptors and most serotonin receptors as well
  • drug which acts as a group - selective agonist for the group II metabotropic glutamate receptors mGluR2 3 It has potent neuroprotective and anticonvulsant
  • modulation of the human metabotropic glutamate receptor 4 hmGluR4 by SIB - 1893 and MPEP British Journal of Pharmacology. 138 6 1026 30. doi: 10.1038 sj