ⓘ Metabotropic glutamate receptor 1

                                     

ⓘ Metabotropic glutamate receptor 1

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of the GRM1 gene have been described but their full-length nature has not been determined.

A possible link was proposed between mGluRs and neuromodulators, as mGluR1 antagonists block the activation of adrenergic receptors in neurons.

                                     
  • The metabotropic glutamate receptors or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic process. They are members
  • Ionotropic glutamate receptors iGluRs form the ion channel pore that activates when glutamate binds to the receptor Metabotropic glutamate receptors mGluRs
  • Metabotropic glutamate receptor 7 is a protein that in humans is encoded by the GRM7 gene. L - glutamate is the major excitatory neurotransmitter in the
  • Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene. Together with GRM6, GRM7 and GRM8 it belongs to group III of
  • Metabotropic glutamate receptor 8 is a protein that in humans is encoded by the GRM8 gene. L - glutamate is the major excitatory neurotransmitter in the
  • Metabotropic glutamate receptor 2 mGluR2 is a protein that, in humans, is encoded by the GRM2 gene. mGluR2 is a G protein - coupled receptor GPCR that
  • Metabotropic glutamate receptor 5 is a G protein - coupled receptor that in humans is encoded by the GRM5 gene. The amino acid L - glutamate is the major excitatory
  • Glutamate receptor metabotropic 6, also known as GRM6 or mGluR6, is a protein which in humans is encoded by the GRM6 gene. L - glutamate is the major excitatory
  • Metabotropic glutamate receptor 3 mGluR3 is a protein that, in humans, is encoded by the GRM3 gene. In humans, mGluR3 is encoded by the GRM3 gene on