ⓘ BCL2L11

                                     

ⓘ BCL2L11

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 BH3. It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-XL, and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor NGF, as well as by the forkhead transcription factor FKHR-L1 FoxO3a, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

BIM expression and activity is regulated at the transcriptional, translational and post-translational levels, consistent expression and activity of BIM shapes the immune response and integrity of the fabric. Cancer cells develop mechanisms that suppress the expression of BIM, which allows tumor progression and metastasis.

                                     
  • redundant in most tissues apart from specific examples. BCL 2 L 2 has been shown to interact with: BCL2L11 BAD, and PPP1CA. GRCh38: Ensembl release 89: ENSG00000129473
  • treatment. Bcl - 2 has been shown to interact with: BAK1, BCAP31, BCL 2 - like 1, BCL2L11 BECN1, BID, BMF, BNIP 2 BNIP3, BNIPL, BAD BAX, BIK, C - Raf, CAPN 2 CASP8
  • interact with: APAF1, BAK1, BCAP31, BCL2L11 BNIP3, BNIPL, BAD, BAX, BIK, Bcl - 2 HRK, IKZF3, Noxa, PPP1CA, PSEN 2 RAD9A, RTN1, RTN4, and VDAC1. GRCh38:
  • The BCL 2 associated agonist of cell death BAD protein is a pro - apoptotic member of the Bcl - 2 gene family which is involved in initiating apoptosis. BAD
  • B - cell lymphoma leukemia 11 A is a protein that in humans is encoded by the BCL 11 A gene. The BCL 11 A gene encodes for a regulatory C 2 H 2 type zinc - finger protein
  • B - cell lymphoma leukemia 11 B is a protein that in humans is encoded by the BCL 11 B gene. BCL 11 B is located on human chromosome 14p32. 2 The mouse analogue is
  • BCL 2 - like 13 apoptosis facilitator also known as BCL 2 L 13 or Bcl - rambo, is a protein which in humans is encoded by the BCL 2 L 13 gene on chromosome 22
  • Bcl - 2 - like protein 10 is a protein that in humans is encoded by the BCL 2 L 10 gene. The protein encoded by this gene belongs to the BCL - 2 protein family
  • lymphoma - extra large Bcl - x L encoded by the BCL 2 - like 1 gene, is a transmembrane molecule in the mitochondria. It is a member of the Bcl - 2 family of proteins
  • also known as bcl - 2 - like protein 4, is a protein that in humans is encoded by the BAX gene. BAX is a member of the Bcl - 2 gene family. BCL 2 family members