ⓘ Fibrinogen alpha chain

                                     

ⓘ Fibrinogen alpha chain

The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin, which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia, and renal amyloidosis. Alternative splicing results in two isoforms that vary in the carboxy-terminus.

                                     
  • T - cell receptor, the fibrinogen alpha chain the integrin alpha chain Hemoglobin, alpha 1 It should be distinguished from the term alpha helix, which refers
  • chains the fibrinogen alpha chain also termed the Aα or α chain encoded by the FGA gene, the fibrinogen beta chain also termed the Bβ or β chain
  • congenital mutations in the fibrinogen alpha chain and classified as a dysfibrinogenemia see Hereditary Fibrinogen Aα - Chain Amyloidosis and, less commonly
  • Fibrinogen beta chain also known as FGB, is a gene found in humans and most other vertebrates with a similar system of blood coagulation. The protein
  • of fibrinogen composed at least in part of a dysfunctional fibrinogen may cause abnormal bleeding and thrombosis. Hereditary fibrinogen Aα - Chain amyloidosis
  • Fibrinogen gamma chain also known as FGG, is a human gene found on Chromosome 4. The protein encoded by this gene is the gamma component of fibrinogen
  • Academy of Arts and Sciences Fellow of the Gemmological Association Fibrinogen alpha chain encoded by the FGA gene Field and Game Australia Fit gap analysis
  • different from thrombin in that they only cleave fibrinogen alpha chain those do cleave both chains are called venombin AB which will end up only producing
  • bleeding. Hereditary fibrinogen Aα - Chain amyloidosis is a sub - category of congenital dysfibrinogenemia in which the dysfunctional fibrinogen does not cause
  • composed of an alpha chain and a beta chain Alpha chain 2b undergoes post - translational cleavage to yield disulfide - linked light and heavy chains that join