ⓘ UDP-glucose 4-epimerase

                                     

ⓘ UDP-glucose 4-epimerase

The enzyme UDP-glucose 4-epimerase, also known as UDP-galactose 4-epimerase or GALE, is a homodimeric epimerase found in bacterial, fungal, plant, and mammalian cells. This enzyme performs the final step in the Leloir pathway of galactose metabolism, catalyzing the reversible conversion of UDP-galactose to UDP-glucose. GALE tightly binds nicotinamide adenine dinucleotide, a co-factor required for catalytic activity.

In addition, humans and some bacterial Gale isoforms catalyzes the reversible formation of UDP - N-acetilgalaktozamin from UDP-GalNAc from UDP - N-acetylglucosamine from UDP-GlcNAc in the presence of nad, the first step in glycoprotein or glycolipid synthesis.