ⓘ Neuropilin 2

                                     

ⓘ Neuropilin 2

Neuropilin 2 is a protein that in humans is encoded by the NRP2 gene.

This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {SEMA domain, immunoglobulin domain IG, short basic domain, secreted, semaphorin 3C} and SEMA3F protein {SEMA domain, immunoglobulin domain IG, short basic domain, secreted, semaphorin 3F}, and interacts with vascular endothelial growth factor VEGF. This protein may play a role in cardiovascular development, Axon guidance, and tumorigenesis. Several variants of transcripts encoding different isoforms have been identified for this gene.

                                     
  • Neuropilin is a protein receptor active in neurons. There are two forms of Neuropilins NRP - 1 and NRP - 2 They are transmembrane glycoproteins, and predominantly
  • Neuropilin - 1 is a protein that in humans is encoded by the NRP1 gene. In humans, the neuropilin 1 gene is located at 10p11.22. This is one of two human
  • Chedotal A, He Z, Goodman CS, Tessier - Lavigne M 1997 Neuropilin - 2 a novel member of the neuropilin family, is a high affinity receptor for the semaphorins
  • Z, Goodman CS, Tessier - Lavigne M September 1997 Neuropilin - 2 a novel member of the neuropilin family, is a high affinity receptor for the semaphorins
  • of both neuropilins and VEGFRs. This receptor complex has increased VEGF signalling activity in endothelial cells blood vessels Neuropilins NRP are
  • Neuropilin NRP and tolloid TLL - like 1 is a protein that in humans is encoded by the NETO1 gene. This gene encodes a predicted transmembrane protein
  • humans is encoded by the PLXNA4 gene. Plexin A4 binds to neuropilin 1 Nrp1 and neuropilin 2 Nrp 2 and transduces signals from Sema3A, Sema6A, and Sema6B
  • October 1998 Semaphorins A and E act as antagonists of neuropilin - 1 and agonists of neuropilin - 2 receptors Nature Neuroscience. 1 6 487 93. doi: 10
  • controls dendritic plasticity and synaptic transmission by downregulating neuropilin - 2 The Journal of Neuroscience. 32 16 5678 5687. doi: 10.1523 JNEUROSCI
  • a VEGF receptor by Terman et al. in 1992 as well. In 1998, neuropilin 1 and neuropilin 2 were shown to act as VEGF receptors. In mammals, the VEGF family
  • Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL November 1998 Neuropilin - 2 is a receptor for semaphorin IV: insight into the structural basis of