ⓘ ST6GAL1

                                     

ⓘ ST6GAL1

Beta-galactoside alpha-2.6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GAL1 gene.

The protein encoded by this gene is a type of the second membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein, which is normally located in the Golgi but which can be processed in a soluble form, is involved in the generation of cell surface determinants of carbohydrates and differentiation antigens HB-6, CDw75, and CD76. This protein is a member of glycosyltransferase family 29. Three variants of transcripts encoding two different isoforms have been found for this gene.

Transcripts of ST6GAL1 are in high endothelial cells of mouse mesenteric lymph nodes and Peyers patches, and he may be involved in B cell homing Peyers patches.

                                     
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