ⓘ GFRA1

                                     

ⓘ GFRA1

Glial cell line-derived neurotrophic factor GDNF and neurturin NTN are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositolGPI-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

                                     
  • neurturin receptor, is a protein that in humans is encoded by the GFRA 2 gene. The GFRA 2 protein is a glycosylphosphatidylinositol GPI - linked cell surface
  • known as the artemin receptor, is a protein that in humans is encoded by the GFRA 3 gene. The protein encoded by this gene is a glycosylphosphatidylinositol GPI - linked
  • as the persephin receptor, is a protein that in humans is encoded by the GFRA 4 gene. GFRα GRCh38: Ensembl release 89: ENSG00000125861 - Ensembl, May 2017
  • from 33 stillborn fetuses were sequenced for mutations in RET, GDNF and GFRA1 Nineteen of the fetuses had BRA, ten had URA and 4 had congenital renal
  • February 2015. This was organized by CORAF in collaboration with AFAAS, GFRAS and ANADER plus 70 participants. Southern Africa Regional Forum for Agricultural