ⓘ Carbonic anhydrase III, muscle specific

                                     

ⓘ Carbonic anhydrase III, muscle specific

Carbonic anhydrase 3 is an enzyme that in humans is encoded by the CA3 gene.

The CAIII carbonic anhydrase III as a member of multigene families, at least six separate genes are known that encode isozymes of carbonic anhydrase. These carbonic anhydrases class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and differently expressed in several cell types. The expression of the CA3 gene is strictly tissue-specific and is present in large amounts in skeletal muscle and much lower levels in cardiac and smooth muscle. CA3 is insufficient for the muscles of myasthenia gravis patients. The proportion of carriers of Duchenne muscular dystrophy have a higher CA3 level than normal. Autoantibodies to CA3 was significantly higher in patients with rheumatoid arthritis, systemic lupus erythematosus and type 1 diabetes. The gene spans 10.3 KB and contains seven exons and its introns are six.

                                     
  • and the dissociated ions of carbonic acid i.e. bicarbonate and hydrogen ions The active site of most carbonic anhydrases contains a zinc ion. They are
  • CA3 may refer to: Carbonic anhydrase III muscle specific a human gene Cornu Ammonis region 3, one of the hippocampal subfields CA - 3 may refer to: Buhl - Verville
  • to this is almost instantaneous with carbonic anhydrase The structure of the active site in carbonic anhydrases is well known from a number of crystal
  • others. Sodium hydrogen antiporter 1 has been shown to interact with carbonic anhydrase II and CHP. It is also the target of the experimental drug rimeporide
  • soleus muscle Immobilization by limb casting does not seem to reduce the relative proportions of muscle - specific proteins, such as carbonic anhydrase II
  • variety. This lack of affinity also applies to Ca2 and K channels, carbonic anhydrase and HMG - CoA reductase. Toxicity information is compiled in the following
  • carbonic anhydrase activation has cognition - enhancing effects but, based upon the clinical use of carbonic anhydrase inhibitors, carbonic anhydrase activation
  • increased affinity for carbon dioxide by the venous blood is known as the Haldane effect. Through the enzyme carbonic anhydrase carbon dioxide reacts with
  • biochemistry and nutrition. This changed in 1940 when carbonic anhydrase an enzyme that scrubs carbon dioxide from blood, was shown to have zinc in its active
  • glaucoma. Carbonic anhydrase inhibitors, such as dorzolamide, brinzolamide, and acetazolamide, lower secretion of aqueous humor by inhibiting carbonic anhydrase