ⓘ Ataxin-2

                                     

ⓘ Ataxin-2

Ataxin-2 contains the following protein domains:

  • A polyglutamine tract in some species located near the amino terminal in primates and between the LSm domains in insects.
  • A PAM2 motif, predicted to associate with the polyA-binding protein.
  • Two LSm domains, which likely allow it to bind RNA.

Potential variant transcripts, lacks an internal coding exon, has been described, but its full nature not sure.

                                     
  • include: Ataxin 1, coded by ATXN1. Mutants of ataxin 1 with a polyglutamine expansion cause SCA1. Ataxin 2 coded by ATXN 2 It is known to cause SCA 2 with
  • Ataxin 7 ATXN7 is a protein of the SCA7 gene, which contains 892 amino acids with an expandable poly Q region close to the N - terminus. The expandable
  • Ataxin - 1 is a DNA - binding protein which in humans is encoded by the ATXN1 gene. Mutations in ataxin - 1 cause spinocerebellar ataxia type 1, an inherited
  • Ataxin - 3 is a protein that in humans is encoded by the ATXN3 gene. Machado - Joseph disease, also known as spinocerebellar ataxia - 3, is an autosomal dominant
  • Ataxin - 2 - like protein is a protein that in humans is encoded by the ATXN 2 L gene. This gene encodes an ataxin type 2 related protein of unknown function
  • Fox - 1 homolog A, also known as ataxin 2 - binding protein 1 A 2 BP1 or hexaribonucleotide - binding protein 1 HRNBP1 or RNA binding protein, fox - 1 homolog
  • Ataxin 1 like is a protein that in humans is encoded by the ATXN1L gene. GRCh38: Ensembl release 89: ENSG00000224470 - Ensembl, May 2017 GRCm38: Ensembl
  • Ataxin 7 - like 2 is a protein in humans that is encoded by the ATXN7L 2 gene. GRCh38: Ensembl release 89: ENSG00000162650 - Ensembl, May 2017 GRCm38: Ensembl
  • Ataxin - 10 is a protein that in humans is encoded by the ATXN10 gene. The autosomal dominant cerebellar ataxias ADCAs are a clinically and genetically
  • repeats in the polyglutamine tract of the ATXN1 gene, which encodes the ataxin 1 protein. This expansion results in a larger than normal number of repeats