ⓘ COPS6

                                     

ⓘ COPS6

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 eIF3 superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.

                                     
  • Ubiquitin carboxy - terminal hydrolase L1, S100A7 and C - jun. COPS 1 COPS 2 COPS 3 COPS 4 COPS6 COPS 7A COPS 7B COPS 8 GRCh38: Ensembl release 89: ENSG00000121022 - Ensembl
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