ⓘ PCBP1

                                     

ⓘ PCBP1

Poly-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene.

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues PCBP3 and PCBP4 which is thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. He, along with PCBP2 and HNRPK corresponds to the main cellular polyrC-binding protein. It contains three K-homologous Kh domains, which may be involved in binding RNA. This encoded protein together with PCBP-2 also function in translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop of the fourth IRES and promote the replication of the virus RNA by binding to its 5 -terminal structure of a clover leaf.

It has also been implicated in translational control of 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and RNA of hepatitis a virus-Encoded protein is also suggested to participate in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.