ⓘ RHEB

                                     

ⓘ RHEB

RHEB also known Ras homolog enriched in brain is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle.

RHEB is a recently discovered member of the RAS superfamily. Being the relative of RAS, overexpression of RHEB can be seen in many human carcinomas. For this reason, the methods inhibit RHEB to control the mTOR pathway are being studied as possible treatments for uncontrolled growth of tumor cells in a number of diseases, especially tuberous sclerosis.