ⓘ ODC1

                                     

ⓘ ODC1

Ornithine decarboxylase is an enzyme that in humans is encoded by the ODC1 gene.

This gene encodes the rate-limiting enzyme of the metabolic pathway for synthesis of polyamines, which catalyzes ornithine to putrescine. The level of enzyme activity varies in response to growth-promoting stimuli and has a high turnover rate compared to other proteins of mammals. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme were found to be located on 2p25, with pseudogene located on 7q31-qter.